Anti-Diabetic Medications: A promising therapeutic approaches for the Management of NAFLD

Document Type : Mini-reviews

Authors

1 Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt

2 Department of Pharmacology &Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.

3 Department of clinical Pharmacology, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt

4 Pharmacology and Toxicology Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.

Abstract

Type 2 diabetes and Nonalcoholic fatty liver disease are two of the most common metabolic diseases in the world, with an increasing prevalence. Patients with T2DM have a two-fold increased risk of developing NAFLD, The evidence that certain antidiabetic drugs boost NAFLD/NASH in T2DM patients is growing. However, there are no specific pharmacologic treatments available. This review aims to outline the data supporting the effectiveness of anti-diabetic drugs in the treatment of NAFLD, besides providing an overview of novel anti-diabetic therapies that have been proposed to achieve this goal. Most of these anti-diabetic agents demonstrate short-term efficacy, but have shown little to no impact on hepatic histology. Only thiazolides and GLP-1 receptor agonists have shown considerable improvement in hepatic histology.

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