Document Type : Mini-reviews
Authors
1
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt
2
Pharmaceutics & Industrial Pharmacy Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.
3
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
4
Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt University, Ismailia 41522, Egypt, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Badr University, Badr City, Egypt.
Abstract
The majority of the pharmaceutically active chemical moieties represent a challenge in their formulation. Most of these drugs have intricate bioavailability issues either related to their low solubility or permeability. Many problems may arise during formulations such as pH dependent ionization, poor drug solubility, limited absorption, unpredicted bioavailability, degradation, metabolism, and cellular efflux. Poor aqueous solubility is a determinate criterion, during formulation and Biopharmaceutical Classification System (BCS) categorization. Among the most important approaches to enhance solubility, the Lipid-Based Drug Delivery Systems (LBDDS). The strategies involving lipid incorporation was a revolutionary step and included: vesicular systems, lipid particulate systems and emulsions.
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