MicroRNA-499-5p and chemokine (C-C motif) ligand18 as new diagnostic markers of Acute Myocardial Infarction

Document Type : Mini-reviews

Authors

1 Ismailia

2 Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

3 Faculty of Pharmacy - Suez Canal University

Abstract

Acute myocardial infarction (AMI) is the acute necrosis of myocardial tissue which named heart block due to chronic and severe ischemia. Acute myocardial infarction stays a main cause of morbidity and mortality worldwide. Accurate and rapid diagnosis is useful for the clinical management and prognosis of acute myocardial infarction early. Thus, exploration of new potential biomarkers that will contribute to this direction is particularly important. Chemokines CCL18 is a class of chemotactic cytokines, come into play in response to acute cardiovascular events, coordinating inflammation, necrosis, neovascularization, and leukocyte recruitment. MicroRNAs (miRNAs) are small (~22-nucleotide) noncoding RNAs regulating gene expression on the post-transcriptional level by binding the target mRNA, leading either to degradation or translational repression. MiRNAs control is critically involved in many biological processes in health and diseases including cardiovascular diseases. Recently, a few numbers of miRNAs are emerging as potential biomarkers of AMI. MiRNA-499-5p is a newly discovered member of miRNAs and is essentially expressed in myocardium.
Key words: CCL18, miRNA-499-5p, acute myocardial infarction.

Keywords

Records of Pharmaceutical and Biomedical Sciences
Volume 7, Issue 1
Chemistry
January 2023
Pages 167-172

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