Review on analytical methods for determination of furosemide

Document Type : Mini-reviews

Authors

1 Pharmaceutical chemistry, Faculty of Pharmacy, Delta university for Science and Technology

2 Pharmaceutical analytical chemistry, Faculty of pharmacy, Mansoura University

3 lecturer, Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

4 Analytical Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.

5 Faculty of Pharmacy -Mansora University

10.21608/rpbs.2024.265078.1266

Abstract

Furosemide (FRS) belongs to loop diuretics. The drug is prescribed for the treatment of hypertension and heart failure. FRS inhibits the reabsorption of electrolytes mainly in the thick ascending limb of the loop of Henle and also in the distal renal tubules. It may also have a direct effect in the proximal tubules. Using a thorough computer assisted literature survey; this review article touches upon the reported analytical methods for the quantification of FRS in raw materials, pharmaceutical dosage forms and biological fluids. Bioanalytical methods are widely used for quantitative estimation of drugs and their metabolites in biological matrices. Various analytical methods such as spectrophotometry, spectrofluorimetry, HPLC, HPTLC, and UPLC have been used in laboratories for the quantitative analysis of this drug in biological samples and pharmaceutical preparations. Therefore, the aim of this review is to give a summary of the current analytical methods used for the assay of the drug.

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Records of Pharmaceutical and Biomedical Sciences
Volume 8, Issue 1
Chemistry
2024
Pages 16-20

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