Use of eosin for spectroscopic determination of Adefovir dipivoxil

Document Type : Original Article

Authors

1 Demonstrator at hue University faculty of pharmacy

2 Professor of Pharmaceutical Analytical Chemistry Faculty of Pharmacy - Suez Canal University

3 Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

4 analtical chemistry faculty of pharmacy suez canal university

Abstract

This paper elucidates a new spectrofluorometric method for the determination of Adefovir Dipivoxil in its pharmaceutical dosage form using Eosin, the colored ion - pair complex was produced at λ em 544 nm and excitation at λ ex 267 in acetate buffer solution with a pH of 3.5. The linearity range was 0.1 – 1.5 µg/ml, with a percentage recovery of 99.31,
and detection limit of 0.032 µg/ml.  The quantification limit was 0.097 µg/ml. The method was successfully applied to determine Adefovir Dipivoxil in its pharmaceutical dosage form. The method was Sensitive, rapid and cost-effective, demonstrating ease of application suitable for routine quality control analysis. 

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Records of Pharmaceutical and Biomedical Sciences
Volume 8, Issue 1
Chemistry
2024
Pages 70-79

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