Urinary Tract Infection and Klebsiella pneumoniae as the second major cause: a mini-review.

Document Type : Mini-reviews

Authors

1 Department of Microbiology and Immunology, Modern University for Technology and Information (MTI), Cairo, EGY

2 Department of Microbiology and Immunology, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt

Abstract

Urinary tract infection (UTI) is a very common infectious condition worldwide that affects people of all genders and ages. Women were more likely than men to have UTIs for a variety of clinical reasons. Klebsiella pneumoniae and Escherichia coli, the most prevalent causes of UTI in the Enterobacteriaceae family, have gradually increased in prevalence over time. Although K. pneumoniae is less common than E. coli, it is substantially more dangerous when it comes to causing UTIs. The global prevalence of ESBL synthesis among K. pneumoniae has grown, posing a significant threat to public health. The genes of the bla-TEM and bla-CTXM variants are the most important in the many bacterial families that produce ESBLs. Carbapenem hydrolyzing-lactamases are becoming increasingly common. The carbapenemases bla-KPC, bla-OXA-48, and Metallo Beta Lactamases, notably bla-NDM, are presently the most effective at hydrolyzing carbapenems and have a wide geographical spread. K. pneumoniae has several virulent features that allow it to spread and evade the host's immune system, resulting in disease in human hosts.

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Records of Pharmaceutical and Biomedical Sciences
Volume 8, Issue 2
Pharmacognosy-Microbiology
2024
Pages 96-105

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