“Examples of Drug Delivery Systems for Delivery of Certain Poorly Water-Soluble Drugs”

Document Type : Mini-reviews

Author

department of pharmaceutics and industrial pharmacy, faculty of pharmacy, Suez canal university.

Abstract

The Biopharmaceutical Classification System (BSC) classifies the drugs according to their solubility in water. Drugs that have poor solubility in water fall under Classes II and IV. A crucial factor affecting biological activity, formulation, and in-vitro and in-vivo biopharmaceutical qualities is aqueous solubility. To improve the extent of water solubility and dissolution rate of an active pharmaceutical ingredient (API), several strategies, such as particle size reduction, inclusion in Nanosponge, and the formulation of Solid lipid nanoparticles, were developed. Solid lipid nanoparticles, both ultra-sonication and solvent evaporation methods were used by preparing a lipid core of stearic acid, Poloxamer 188, and propylene glycol (co-solvent) then mixed with the drug dissolved in ethanol followed by Lyophilisation. Nanosponge is a cross-linked β-Cyclodextrin polymer structured in nano-size forming networks prepared by the solvent technique using N, N-Caronyldiimidazole (CDI) as a cross-linker. The drug was loaded into the prepared Nanosponge with the aid of ultrasonication followed by lyophilization.

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Records of Pharmaceutical and Biomedical Sciences
Volume 8, Issue 3
Pharmacology- Pharmaceutics
2024
Pages 41-45

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