A recent review on polymeric nanoparticles: Structure, Classification, and preparation methods

Gad, Shadeed; Awd, Heba; Ghorab, Mamdouh; Abdelwahab, Nashwa; Nasr, Ali

doi:10.21608/rpbs.2024.285214.1293

A recent review on polymeric nanoparticles: Structure, Classification, and preparation methods

Document Type : Mini-reviews

Authors

¹ Faculty of Pharmacy - Suez Canal University

² Department of Pharmaceutics, Faculty of Pharmacy, Sinai University, Al Qantarah Sharq 41636, Egypt

³ Department of Pharmaceutics, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt

⁴ Department of Pharmaceutics, Faculty of Pharmacy, Port Said University, Port Said 42526, Egypt

10.21608/rpbs.2024.285214.1293

Abstract

Polymeric nanoparticles, also known as NPs, are particles with a size range of 1 to 1000 nm. They can have active chemicals adsorbed onto their surface or trapped within the polymeric core. Both nanocapsules and nanospheres, which are identified by their morphological structures, are referred to as "nanoparticles." Polymeric nanoparticles have demonstrated significant promise in the targeted delivery of pharmaceuticals for many medical conditions. In this review, we go over the most commonly utilized methods for creating and focusing on PNP types and the classification of biodegradable polymers. Applications in biomedicine and features of polymeric nanoparticles as drug carriers besides the Limitations regarding the development of polymeric nanoparticles are also discussed.
Many studies have been conducted to better understand the physicochemical behavior of polymeric nanoparticles (NPs); nonetheless, one of the primary challenges in characterizing these particles is their microsize. Only by combining many analytical approaches is it possible to characterize these drug carriers physiochemically. The most significant obstacle that still must be overcome is the clarification of drug association processes with polymeric nanoparticles. Numerous advancements have already been made in the production of more stable polymeric NP formulations and the body of knowledge pertaining to the physicochemical phenomena involved, which may increase the systems' potential for clinical application. In its possible applications, neither the environment nor human health are at risk.

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