Document Type : Mini-reviews
Authors
1
Faculty of Pharmacy - Suez Canal University
2
Pharmacy Department, The Armed Forces Medical Complex, Qobry El Qoba, Ministry of Defense, Egypt
3
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Egyptian Russian University, Cairo 11829, Egypt.
4
scu
5
Pharmaceutics & Industrial Pharmacy Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.
6
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt
Abstract
Aminoglycosides are a class of potent antibiotics widely used in the treatment of severe bacterial infections. However, their clinical efficacy is often limited by issues such as poor bioavailability, systemic toxicity, and the emergence of antibiotic resistance. To overcome these challenges, various drug delivery systems have been developed to enhance the therapeutic outcomes of aminoglycosides. This review article provides a comprehensive overview of the different drug delivery systems employed for aminoglycosides, with a specific focus on amikacin. The review discusses the rationale behind the use of drug delivery systems, the various types of delivery systems available, their advantages and limitations, and recent advancements in the field. The aim is to provide a detailed understanding of the current state-of-the-art drug delivery systems for aminoglycosides, particularly amikacin, and their potential in improving the clinical outcomes of aminoglycoside therapy.
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