Fecal Microbiota Transplantation's Positive Effects on Ulcerative Colitis

Document Type : Original Article

Authors

1 Department of Microbiology and Immunology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa 11152, Egypt

2 Faculty of Pharmacy, Delta University for Science and Technology, Gamasa 11152, Egypt

3 Delta University for Science and Technology, Gamasa 11152, Egypt

Abstract

Ulcerative colitis (UC) is a severe disease caused by immune system abnormalities leading to inflammation and ulcers in the large intestine. Dysregulation of gut microbiota is a key factor in UC. Fecal microbial transplantation (FMT) involves transferring fecal matter from a healthy donor to a recipient to alter gut microbiota and improve health. This study explored the effects of FMT on gut microbiome abundance and virulence genes in UC patients. Thirty metagenomic samples were retrieved from the NCBI database published under the project PRJNA768409. In that project samples were collected from three groups of participants. The first group is “Before” which includes patients with UC before administering FMT. The second group is “After” which includes patients with UC after administering FMT, after FMT and from donor participants. The third group is “donor” which includes healthy participant that gives their healthy feces for the “before” group. Results showed that 50% of the samples had decreased virulence genes, with reduced Actinobacteria and Bacteroidetes and increased Firmicutes after FMT. FMT significantly impacts UC patients, potentially reshaping the gut microbiome. Pre-FMT metagenomic analysis of donor samples is recommended to ensure safety.

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Records of Pharmaceutical and Biomedical Sciences
Volume 8, Issue 2
Pharmacognosy-Microbiology
2024
Pages 157-166

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