A Brief Review on Analytical Techniques for Quantitative Determination ‎of Rosuvastatin and Losartan in Different Matrices.‎

Cardiovascular diseases, including coronary heart disease (CHD), ‎heart failure, and hypertension, represent major global contributors ‎to morbidity and mortality. CHD is primarily a pathological ‎condition affecting the coronary vasculature, which can be ‎exacerbated by thrombotic complications, potentially leading to ‎acute myocardial infarction (AMI). Survivors of AMI are ‎predisposed to an elevated risk of heart failure and sudden cardiac ‎death due to ventricular arrhythmias. Additionally, persistent ‎hypertension is a critical risk factor that can precipitate CHD, heart ‎failure, and cerebrovascular events such as stroke. Given the ‎multifactorial etiology of cardiovascular diseases, patients ‎frequently require polypharmacological interventions targeting ‎interconnected pathological pathways.‎
This brief review provides a comprehensive overview of analytical ‎methodologies employed for the quantification of key ‎cardiovascular therapeutic agents, namely Rosuvastatin (ROS) and ‎Losartan (LOS). The objective is to furnish researchers with up-to-‎date insights into advanced analytical techniques utilized for the ‎determination of these pharmaceutical compounds, both as ‎monotherapeutic agents and in combination with other ‎cardiovascular drugs. Furthermore, this review encompasses ‎fundamental physicochemical properties, pharmacological ‎mechanisms of action, and therapeutic relevance of the cited ‎agents. The compiled analytical approaches include ‎pharmacopeial, chromatographic, spectrophotometric, and other ‎advanced techniques, all validated in accordance with International ‎Council for Harmonisation (ICH) guidelines.‎