The role of vitamin D receptor gene polymorphisms in Type 2 Diabetes Mellitus Susceptibility and Pathogenesis

Document Type : Mini-reviews

Authors

1 Pharmacy college Suez Canal university

2 Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Abstract

Type 2 Diabetes Mellitus (T2DM) is a multifactorial disease influenced by both genetic and environmental factors. Among the genetic factors, vitamin D receptor (VDR) gene polymorphisms have been studied for their potential role in T2DM susceptibility. Vitamin D, through its receptor (VDR), plays a crucial role in various biological processes, including glucose metabolism, insulin secretion, and inflammation regulation. Vitamin D deficiency is associated with diabetes mellitus. In addition, genetic variations in the VDR gene could influence an individual’s risk of developing T2DM through calcium metabolism alteration and modulation of insulin secretion. Three single nucleotide polymorphisms BsmI, ApaI and TaqI of the VDR gene were located in key untranslated regions that influence gene expression. Moreover, FokI is a T > C substitution occurring in exon 2. These four VDR gene polymorphisms have been shown to impact insulin production and secretion, suggesting their potential involvement in the development of T2DM.
Keywords: T2DM; VDR gene polymorphisms; BsmI; ApaI; TaqI; FokI

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Records of Pharmaceutical and Biomedical Sciences
Volume 9, Issue 1
Chemistry
March 2025
Pages 48-57

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