Investigating Nitrogen Containing Compounds as Promising Anticancer Agents

Elzoghbi, Noura Zakaria; Kishk, Safaa; Darwish, Khaled Mohamed; Salama, Ismail

doi:10.21608/rpbs.2025.402080.1386

Investigating Nitrogen Containing Compounds as Promising Anticancer Agents

Document Type : Original Article

Authors

¹ Department of Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

² Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

³ a. Department of Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University b. Department of Medicinal Chemistry, Faculty of Pharmacy, Galala University, New Galala 43713, Egypt.

⁴ Department of Medicinal Chemistry, Faculty of Pharmacy - Suez Canal University

10.21608/rpbs.2025.402080.1386

Abstract

Cancer is known as a large group of diseases with one shared thing that normal cells become cancerous cells which speedily multiply then spread. Colorectal cancer is the one of top two most common cause of death worldwide. Most Chemotherapy drugs can badly damage vital human organs so medicines are prescribed with the chemotherapy for the protection of body normal cells. New targets for cancer treatment have been over years to help discover new drugs with higher potency and lower side effects. New thiazole based compounds can be developed by reacting various chemical scaffolds are considered promising anti-cancer agents. They are reported with the inhibitory effect on different kinases including epidermal growth factor receptor (EGFR) that play a main role in cancerous cell growth, proliferation and metastasis through the transmission of cellular signaling. Molecular docking analyses were performed to assess the binding affinities and interaction patterns of the compounds within the active site of EGFR. Furter, in silico toxicity and target interaction predictions were carried out for the five compounds using the ProTox 3.0 platform.

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