Estrogen receptor alpha XbaI polymorphism is associated with higher relaxin-3 levels in women with metabolic syndrome

Mehanna, Eman T.; Mesbah, Noha M.; Ghattas, Maivel H.; Abo-Elmatty, Dina M.

doi:10.21608/rpbs.2018.5916

Estrogen receptor alpha XbaI polymorphism is associated with higher relaxin-3 levels in women with metabolic syndrome

Document Type : Original Article

Authors

¹ Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt

² Department of Medical Biochemistry, Faculty of Medicine, Port Said University, Port Said, 42526, Egypt

10.21608/rpbs.2018.5916

Abstract

Relaxin-3 is known to play a role in appetite regulation, increasing food intake and body weight. This study aimed to assess the relation of relaxin-3 with ERS1 XbaI and PvuII polymorphisms. One hundred female patients with metabolic syndrome were investigated. The genotypes of ESR1 XbaI and PvuII polymorphisms were assessed with PCR-RFLP. Serum relaxin-3 level was measured for all participants using ELISA. Higher relaxin-3 levels showed association with the minor GG genotype of ESR-1 XbaI polymorphism but not PvuII polymorphism.

Keywords

Main Subjects