Investigation of In-Vitro Cytotoxic and Potential Anticancer Activities of Flavonoidal Aglycones from Egyptian Propolis

Ibrahim, Reham; Seif El-Din, Ahmed; Abu-Serie, Marwa; Abd El Rahman, Nevine; El-Demellawy, Maha; Metwally, Aly

doi:10.21608/rpbs.2018.5924

Investigation of In-Vitro Cytotoxic and Potential Anticancer Activities of Flavonoidal Aglycones from Egyptian Propolis

Document Type : Original Article

Authors

¹ Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt

² Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt

³ Medical Biotechnolog Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City, Egypt

⁴ Pharmaceutical & Fermentation Industries Development Center, City of Scientifc Research and Technological Applications, Alexandria, Egypt

⁵ Pharmaceutical & Fermentation Industries Development Center, City of Scientific Research and Technological Applications, Alexandria, Egypt

10.21608/rpbs.2018.5924

Abstract

The in-vitro anticancer activity of Egyptian propolis ethanol extract as well as two isolated ﬂavonoidal aglycones, tectochrysin and quercetin-3,3’-di-O-methylether,was assayed using neutral red uptake method on human breast cancer (MCF-7) and colorectal adenocarcinoma (Caco-2) cell lines, in addition to their in-vitro cytotoxic eﬀect to normal human peripheral blood mononuclear cells (PBMCs). Egyptian propolis ethanol extract and quercetin-3,3’-di-O-methylether showed both high activity and selectivity towards the two tested cell lines suggesting them as eﬀective, safe and selective anticancer candidates against both breast and colorectal cancer.

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