Investigation of the gastroprotective activity of some drugs in indomethacin-induced gastric lesion in rats

Document Type : Original Article

Authors

1 Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

2 Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egyp

Abstract

Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) increases the risk of severe gastric events. To minimize these risks, patients often require concomitant acid-suppressive therapy. This study was conducted to investigate the putative gastroprotective effect of sildenafl, verapamil and propranolol and possible mechanisms
underlying the effect of these drugs in experimentally-induced gastric lesions in rats. Rats were assigned to vehicle (saline), control (indomethacin, 30-mg/kg, p.o.), sildenafl (10-mg/kg, p.o.), verapamil (10 mg/kg, p.o.), propranolol (10 mg/kg, p.o.) and ranitidine (50-mg/kg, p.o); the drugs were administered 30-minute prior to indomethacin. After
4-hours, all rats were sacrifced, and stomach of each rat examined for gastric lesions either for biochemical or histopathological analysis. Indomethacin induced marked ulcerative lesions in form of strikes in the gastric mucosa. Furthermore, pre-treatment with sildenafl, verapamil, and propranolol signifcantly reduced gastric acid secretion,
ulcer scores, and lipid peroxides. Moreover, they markedly protect the stomach against indomethacin effect. The results confrm that each drug has a gastroprotective effect but with different mechanisms in prevention.

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