Development and evaluation of a floating in situ gelling liquid formulation of a locally acting H2-antagonist

Document Type : Original Article

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1 Department of Pharmaceutics, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11651, Egypt

2 Department of Pharmaceutics, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11651, Egypt

Abstract

In the present study, floating in situ gelling liquid formulation for controlled delivery of ranitidine was formulated using gellan gum (gelling polymer), calcium carbonate (gas-forming agent) and ranitidine. Gellan gum floating in situ gelling systems were prepared by dissolving varying concentrations of gellan gum in deionized water containing sodium citrate and calcium chloride, to which varying concentrations of drug and calcium carbonate were added and dissolved by continuous stirring. Prepared formulations were evaluated for viscosity, gelation behavior, floating properties (floating lag time and floating duration time), drug content and in-vitro drug release. Formulation variables such as concentration of gellan gum, calcium carbonate and drug signifcantly affected the formulation viscosity, floating behavior and in-vitro drug release. Analysis of the release kinetic data showed that the drug release from in situ gel followed a diffusion control mechanism.

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